Deep Dive - Season 3

Dr. Alireza Atri, the director of the Banner Sun Health Research Institute in Sun City, AZ, joined Deep Dive from the floor of the 2021 Alzheimer’s Association International Conference to discuss the recently published and presented Appropriate Use Criteria for aducanumab, or Aduhelm, Biogen’s newly approved anti-amyloid agent for the treatment of Alzheimer’s disease.

Dr. Carlos del Rio spoke on the FDA’s authorization of a booster COVID-19 vaccine dose for immunosuppressed patients this week, supported by data showing that immunocompromised patients including organ transplant recipients generally fare worse in COVID-19 vaccine response.

Julio Aguirre-Ghiso, PhD, discusses his new role leading the new Cancer Dormancy and Tumor Microenvironment Institute at Albert Einstein Cancer Center, his plans for the institute, and the unmet need addressed by the first-of-its-kind program

As use of reference bevacizumab (Avastin) for the treatment of macular degeneration has increased over the past decade, payers have begun to recommend bevacizumab biosimilars for the same indication. However, some institutions, including the American Academy of Ophthalmology, say that there needs to be more evidence for the use of these biosimilars for macular degeneration and that recommending them for use is premature.

Ilana Cass, MD discusses New Hampshire’s recently enacted abortion ban, which prohibits abortions after 24 weeks gestation, even in cases like rape, incest and fatal fetal anomaly. The ban became law in June as part of the state’s 2-year budget plan, and includes criminal and civil penalties for health care providers who perform abortions after 24 weeks gestation.

Dr. Daniel Streetman joins Deep Dive to discuss what ways the immunocompromised population has been impacted by the COVID-19 pandemic. He talks about the risk of COVID-19 for immunocompromised people, how they respond to COVID-19 vaccines, what they can do to remain safe during the pandemic, booster doses of vaccines for immunocompromised people and if future variants are a concern for this population.

Dr. Kulleni Gebreyes, director of the Health Equity Institute at Deloitte, joins Deep Dive to discuss race and healthcare inequities, the constructs of race in healthcare, how addressing inequities makes economic sense but also whether the goal of eliminating healthcare inequity is too aspirational, too lofty of a goal.

Dr. David Weber joins Deep Dive to discuss the logistics and reasoning behind the FDA's decision around COVID-19 vaccine booster dose authorization—both for severely immunocompromised patients as well as the general adult population. Dr. Weber gave insight into the pros and cons of the US pursuing COVID-19 vaccine booster doses at a time when just over half the population is fully vaccinated.

A recent study documented a connection between patients with gingivitis and patients with clinical depression. Dr. Sam Low joins us to discuss the potential link between oral health and mental health, the oral systemic connection and why gum health should be promoted more by dentists, as well as by medical doctors.

Yan Lavrovsky, MD, PhD discusses the RPH-104 Molecule, a biological project that is currently being developed to treat a variety of inflammatory diseases, metabolic diseases, recurrent fever, joint lesions, and rashes. Dr. Lavrovsky discusses why the FDA approval of the molecule is so groundbreaking, future research, and what first sparked his team’s interest in researching and developing the RPH-104 molecule.

Infection preventionists hold a unique place in a hospital hierarchy. States do not mandate that hospitals have an infection preventionist on staff. They also don’t mandate that professionals who work as infection preventionists need to have certification as such. Lisa Waldowski talks about the challenges that infection preventionists face, challenges involving COVID, and also non-COVID-related challenges.

The COVID-19 pandemic forced medical practices to rapidly change their in-person visits to virtual ones, but how do their patients feel about these new forms of health care? In a recent study, a survey-based assessment of varied telemedicine experiences was evaluated by a group of investigators led by Kara L. Watts, MD, who discusses their findings in this interview.

On this episode of Deep Dive, Phil Tucak describes the devastating aftermath of the Australian wildfires and their impact on wildlife, plus other detailed information on the topic including wildlife care facilities that have been established, a recent mouse plague, and more.

How can researchers encourage patient participation in clinical trials and ensure their comfort during the process? Dr. Miguel Villalona-Calero discusses several aspects of clinical trials from a patient standpoint, from common misconceptions to what the most rewarding aspects are.

Dr. Deena Kuruvilla, a headache specialist and the medical director of the Westport Headache Institute, discusses the latest updates in the care of patients with migraines. She offered insight into the access challenges faced by patients and the latest data on the newest therapies to enter the market and the ongoing clinical development in the pipeline.

Previewing New Jersey’s first free-standing cancer center, Dr Steven Libutti, director of the Rutgers Cancer Institute of New Jersey, speaks with The American Journal of Managed Care on how the upcoming Jack and Sheryl Morris Cancer Center will open possibilities in cancer care that were otherwise unavailable in the state. Dr Libutti discusses the capabilities in oncology care and clinical trial research that will be provided at the Rutgers-affiliated center, and its implications for a state marked by one of the highest cancer rates nationwide.

Josh Ludwig spoke with CancerNetwork about how ScaleReady, a joint venture between industry leaders launched in January, is equipped to make cell and gene therapy practical and viable. Ludwig touched on the partnership, as well the G-Rex platform, important processes for successful commercialization of cell and gene therapy, and what’s next for ScaleReady.

Stephanie Mercado, CEO and Executive Director of NAHQ (National Association for Healthcare Quality) discusses NAHQ’s mission to improve healthcare quality and what improvements, as well as shortcomings have been made. Mercado also shared what steps need to be taken in healthcare as a whole to continue improving the quality of care.

Christie Ballantyne, MD, Director of the Center for Cardiometabolic Disease Prevention at Baylor College of Medicine, discussed the possible issues his field sees in the rate of innovation and research relative to the process of regulation. Ballantyne also highlighted upcoming drug classes he has the most interest in for cardiovascular disease management, as well as his reasoning for why currently available agents are not being best utilized still.

Next month, the American Academy of Pediatrics will be publishing Dr. Candice Jones' book, “High Five Discipline: Positive parenting for happy, healthy, well-behaved kids.” We took a deep dive into lessons that both pediatricians and parents can glean from this book, from the difference between positive and negative parenting, to how to handle those sometimes-tumultuous teenage years.

Utilizing its innovative whole-body scanner, Q Bio develops breakthrough technology to measure changes in the human body like never before. Q Bio unveiled the first clinical "digital twin" platform, Q Bio Gemini, to capture and monitor comprehensive baseline patient health in a scalable virtual model. In this interview, Q Bio CEO Jeff Kaditz discusses the company’s leading technology that is driving this innovation.

Doctor Kevin Kavanagh has been out in front of developments during the COVID pandemic, sometimes way out in front. He called for booster shots for older Americans weeks before the CDC did. He also foresaw, and wrote about, the dangers the delta variant presents before most other medical experts did. But what made this retired ear, nose and throat surgeon take such a deep dive into the world of infection prevention?