Deep Dive - Season 5

After a year of controversy and conversation in Alzheimer disease that saw the first approval for the field in 2 decades, Dr. Anton Porsteinsson shared his perspective on the progress made and commented on the agents moving through the pipeline and the state of things heading into 2022.

The pandemic has brought on a new era of flexible work in healthcare, as providers now utilize telehealth technology in their day to day. For Dr. Elizabeth Hawk, a radiologist and single mother, more flexible work arrangements can be incredibly beneficial, but for women in radiology, a more flexible work environment may also have its drawbacks. In this episode of Deep Dive, Dr. Hawk expands on the pros and cons of flexible work environments and the implications it may have on women in radiology.

Although equally effective and less expensive than reference products, biosimilars continue to face substantial challenges limiting its uptake among providers and patients. Dr. Sameer Awsare, MD, FACP, associate executive director for The Permanente Medical Group, addresses the current state of biosimilar uptake in the United States and his predictions for the near future.

Based on a presentation she gave at the 2021 American Society for Reproductive Medicine (ASRM)’s Annual Meeting, Dr. Alice Domar outlines the importance of mental health for patients with pregnancy loss. Get Dr. Domar’s advice on what not to say to patients, when the right time may be to discuss treatment options/counseling services, and how to be emotionally considerate toward patients throughout the process.

Antimicrobial resistance is a paramount concern in medicine. And as it can take many years to develop new antibiotics, alternative therapies are being considered. For example, bacteriophage is a therapeutic platform being used internationally and is emerging her in the United States. Locus Biosciences CEO Paul Garofolo provides an overview of bacteriophage and its potential therapeutic applications.

Rodrigo Cerdá, M.D., M.P.H., who was recently promoted to the position of executive vice president of health services and chief medical officer of Independence Blue Cross (IBX), discusses the role of medical director at IBX and how the medical review functions at the company are organized. Wehrwein and Cerdá also discussed prior authorization and how IBX is addressing social determinant of health and health equity issues.

Dr. Keipp Talbot discussed with us the currently increasing rate of influenza in the US, as well as the state of research into flu vaccination—a topic which has significant scrutiny right now given the efficacy of COVID-19 vaccines. Among those options for advancing flu vaccines were products designed for older and/or immunocompromised patients, as well as mRNA technology. Additionally, she discussed how, contrary to common belief, flu research may be better informed by sequencing and screening strategies implemented by COVID-19 response—not the other way around.

Drug development via a pathway approach creates the potential to treat multiple diseases with a single therapy. Alyssa Johnsen, MD, PhD, joins Deep Dive to discuss how the ongoing research by Janssen Immunology continues to confirm their IL-pathway model to treating immune mediated diseases.

Arjun Srinivasan, MD, is the Associate Director for Healthcare Associated Prevention Programs, Division of Healthcare Quality Promotion at the Centers for Disease Control and Prevention. One of Doctor Srinivasan’s concerns is the growing threat posed by pathogens that are becoming immune to antibiotics. In the interview, he talks about ways the government might try to encourage pharmaceutical companies to develop new, more effective antibiotics.

Geolani Dy, MD, and Gaines Blasdel discuss what urologists can do to help transgender patients and how this role will evolve over time. Dy is an Assistant Professor of Urology and Plastic and Reconstructive Surgery at Oregon Health & Science University in Portland, Oregon, who specializes in gender-affirming surgery within the OHSU Transgender Health Program. She also led the creation of Transgender and Non-Binary Surgery Allied Research Collective (TRANS-ARC), which focuses on patient-centered outcomes of genital gender-affirming surgery. Blasdel is a transgender man and gender affirming surgery outcomes researcher at NYU Langone Health in New York City, New York. He is also a TRANS-ARC Steering Committee Member.

Dr. Jean Talleyrand, Co-Founder and Vice-Chairman of the Clinical Endocannabinoid System Consortium (CESC) and founder of MediCann, joins us to discuss medical cannabis research and ongoing projects he is involved in. As a third generation medical provider, Dr. Talleyrand offers his insight into how medical cannabis can be added as a tool for any doctor to consider.

CAR-T cell therapy has dramatically changed the game for many cancer types. Recent findings in a trial examining a second-line CAR-T therapy option for large B-cell lymphoma showed a potential to shift the standard of care. In an interview with CURE®, Joseph McGuirk, D.O., discussed the inspiring ways in which CAR-T therapy advancements are transforming the cancer landscape.

Christine Dehlendorf, MD, MAS, is passionate about returning women to the center of decisions made about contraception and family planning. To some the term “patient centered counseling” may sound overused, even gimmicky. But when the topic is how, when, or if a woman wants to conceive, the first job of the clinician is to elicit the patient’s needs and desires as the patient defines them, not to forge ahead based on a preconceived notion of what “a patient like this” should want or should do. Her research focuses on how to facilitate this shift of choice fully back into the patient’s hands.

Oncology Nursing News® meets with the lead investigator of a study which revealed that children under 5 are at the highest risk of hearing loss following treatment with cisplatin chemotherapy. Dr. Bruce Carleton discusses the benefits and risks associated with this life-saving therapy, and the challenge of balancing these risks when treating young children with cancer.

Sarah Temkin, Associate Director for Clinical Research in the Office of Research on Women’s Health at the National Institutes of Health, discusses how the NIH Office of Research on Women’s Health are involved in health care and pharmacy practice. She talks about clinical data pertaining to biological and sociological variables and clinical trials that have been conducted. Additionally, she addresses the upcoming goals and projects on the horizon for the NIH ORWH that may impact the pharmacy field.

Dr. Kathleen B. Digre focuses on opportunities for women leaders in the field of neurology. We spoke at length about her past and present leadership roles, and she shared her perspective on how the field has changed and provided more opportunity for females in the space.

On this episode of Deep Dive, Dr Cynthia Otto sits down with dvm360 to discuss the life of a detection dog at the University of Pennsylvania’s Working Dog Center and explains how they train these dogs to smell anything from explosive devices to COVID-19.

Findings of a recent Health Affairs study showed that race and bias were significantly associated with negative patient descriptors in the electronic health record. On today’s Deep Dive, Michael Sun, first author of the study and a medical student at the Pritzker School of Medicine at the University of Chicago, discusses the impact of potentially stigmatizing language on racial and ethnic health care disparities and building awareness among clinicians.

In recognition of Black History Month, Ozuru O. Ukoha, MD, highlights barriers that may hinder participation of Black patients in clinical lung cancer research, how these disparities impact outcomes, and how initiatives such as the American Lung Association’s Awareness, Trust and Action campaign may work to increase enrollment. He not only discusses short-and long-term goals of the campaign, but what the oncology community as a whole can do to be more inclusive of diverse patient populations.

Women physicians today are suffering from record-breaking levels of burnout. Tammie Chang, MD, was one of those women. When she began to feel dangerously burnt out, she decided to write a self-help book for women struggling to balance their personal and professional lives. Tammie writes for these women in hopes that they can become empowered and learn to set healthy boundaries in their daily lives.

In this episode of Deep Dive, Peter Wehrwein, managing editor of Managed Healthcare Executive, speaks with Mark Nolan, chief operating officer of Hint Health. Hint Health is a company in the business of supporting primary care direct contracting. Direct contracting cuts out insurance companies. Instead of accepting insurance payment, practices are paid a flat fee. Wehrwein and Nolan discuss how direct primary care differs from concierge care and how CMS’ value-based payment models and ACOs fit with what Hint is doing.

Charcot-Marie-Tooth (CMT) may be the most common condition involving the peripheral nervous system. However, it's estimated that only 150,000 Americans and 3 million people across the globe live with it, making it a rare disease. In an interview with Giuliana Grossi, Associate Editor, HCPLive, Dr. Keith Fargo discusses some of the challenges in the field and addresses the importance of being cognizant of the blood-nerve barrier when treating patients and developing therapies for CMT.

As we begin to emerge from the shadows of the COVID-19 pandemic, it is clear that radiologists, particularly breast radiologists, are faced with significant challenges. On top of workload issues, they may be communicating a greater number of advanced breast cancer diagnoses due to pandemic-related screening delays. However, as Amy K. Patel, MD, points out, there are also emerging opportunities to save lives.

In this segment, Practical Cardiology sits down with Dr. Ziyad Al-Aly to discuss a recent study he led examining long-term cardiovascular outcomes among patients with COVID-19. An analysis with data from more than 10 million patients, Al-Aly’s work provide insight into the immediate risk of negative cardiovascular outcomes associated with COVID, but also shed light on long-term effects and the impact of COVID-19 severity on this apparent increase in risk for negative outcomes.